Manipulation of cytokine secretion in human dendritic cells using glycopolymers with picomolar affinity for DC-SIGN† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01515a Click here for additional data file.
نویسندگان
چکیده
1 Clinical Sciences Research Laboratories, University of Warwick, Coventry CV2 2DX, UK 2 University Hospital Coventry & Warwickshire NHS Trust, Coventry CV2 2DX, UK 3 Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK 4 Chelsea & Westminster Hospital, Imperial College School of Medicine, London SW10 9NH, UK 5 Glycobiology Institute, University of Oxford, Oxford OX1 3QU, UK 6 Universität zu Lübeck, 23562 Lübeck, Germany 7 Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK 8 Polymer Chemistry Laboratory, School of Engineering and Materials Science, Queen Mary University, London E1 4NS, UK
منابع مشابه
Manipulation of cytokine secretion in human dendritic cells using glycopolymers with picomolar affinity for DC-SIGN.
The human C-type lectin DC-SIGN (CD209) is a significant receptor on the surface of dendritic cells (DCs) - crucial components of host defense that bridge the innate and adaptive immune systems. A range of linear glycopolymers, constructed via controlled radical polymerization techniques have been shown to interact with DC-SIGN with affinities in the physiologically active range. However, these...
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2017